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Denis Noble is Director of Computational Physiology at Oxford University. His research is focussed on using computer models of biological organs and systems to interpret function through from the molecular to the whole body levels. He was the first to develop computer models of the heart, published in Nature in 1960. With his international collaborators, he has used supercomputers to create the first virtual organ, the virtual heart. As Secretary-General of the International Union of Physiological Sciences, he played a major role in launching the Human Physiome Project, an international project to use computer simulations to create the quantitative physiological models necessary to interpret the genome. He is one of the founders of the new field of Systems Biology and is the author of the first popular science book on five other languages.

Denis Noble has received many national and international prizes and distinctions for his work, including election as a Fellow of the Royal Society, Honorary Fellow of the Royal College of Physicians. He is an Honorary Foreign Member of the Académie Royale de Médecine de Belgique and has received the Pavlov Medal of the Russian Academy of Sciences. He holds several honorary doctorates and was recently made Docteur Honoris Causa, Université de Bordeaux. In addition to English, he has lectured and published in French, Italian, Occitan, Japanese and Korean.